Category Archives: Cancer Immunotherapy

Two Cancer Immunotherapy Targets are Better Than One

In cancer patients undergoing adoptive T cell therapy, T cells that recognise and react to an abundant protein fragment expressed by a tumour cell are infused into the bloodstream. These protein fragments are known as tumour-associated antigens. Because cancers are … Continue reading

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Using Viruses to Tune T Cell Functionality

As we have learned more about the world of microbes, it’s become clear that it’s possible to use bacteria and viruses as treatments against disease. But although microbes often work incredibly well at protecting against infections or attacking tumours, we … Continue reading

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Posted in Bacteria, Cancer Immunotherapy, Disease, Health, Immunology, Microorganisms, Oncolytic Virus, Personalised Medicine, Science, Vaccines, Virology, Viruses | Leave a comment

Exosomes may promote cancer spread after radiation therapy

Exosomes are small vesicles that are packed full of microRNAs, proteins, lipids and other biological molecules that get released from most cells in the body. In different biological settings, exosomes can be considered as little bubbles of joy or little … Continue reading

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Convection currents help to deliver oncolytic virus in the brain

In a Phase I clinical trial for recurrent glioma run by the University of Alabama in the USA, 15 patients have received a steady stream of oncolytic reovirus (up to 10^10 TCID50) infused directly into their brain tumour. This novel … Continue reading

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Posted in Cancer Immunotherapy, Immunology, Oncolytic Virus, Science, Viruses | Leave a comment

From tumour biopsy to personalised cancer treatment in 16 days

Every cancer patient essentially has a unique genetic disease. While certain key ‘driver’ mutations in genes such as TP53 and KRAS are almost always present, many other ‘passenger’ mutations are collected as tumours evolve that shape their genetic footprint. These … Continue reading

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Posted in Cancer Immunotherapy, Immunology, Mutations, Personalised Medicine, Science | Leave a comment