Category Archives: Cancer Immunotherapy

Using pseudogene expression profiles to classify tumours & predict cancer prognosis

Pseudogenes are genes that have accumulated so many mutations that they can’t code for or create proteins any more. Now, scientists at the MD Anderson Cancer Centre have shown that characterising a cancer patient’s catalogue of pseudogenes can not only … Continue reading

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Moving towards a universal immunosignature diagnostic platform for cancer

Scientists at Arizona State University have moved closer towards a universal immunosignature diagnostic platform for cancer. Publishing in the journal PNAS, they describe the use of a platform that applies antibodies circulating in the blood of cancer patients to a … Continue reading

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Latest research​ suggests that the presence of Tregs might not be bad news for every type of cancer

Regulatory T cells, or Tregs, are immune cells that are typically considered bad news for cancer patients. That’s because these cells are immunosuppressive, and can prevent the patient’s own immune cells from attacking and clearing their tumour. Essentially, the Tregs … Continue reading

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Overexpressing Notch1 in regulatory T cells unlocks T cell proliferation

Tumours typically recruit regulatory T cells (Tregs) to suppress the activity of other T cells. This effectively prevents T cells from targeting – and destroying – the tumour. Now, a team of scientists from Harvard Medical School have shown that … Continue reading

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Blood pressure during treatment impacts oncolytic virus therapy

In an exciting new study released from the Mayo clinic, oncolytic vesicular stomatitis virus (VSV) was infused into mice with myeloma that had either just exercised (high blood pressure; ‘EX’) or were anaesthetised (low blood pressure; ‘ISO’). Mice that had … Continue reading

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