Category Archives: Oncolytic Virus

Using Viruses to Tune T Cell Functionality

Posted on 13 July 2020 by mmmbitesizescience

As we have learned more about the world of microbes, it’s become clear that it’s possible to use bacteria and viruses as treatments against disease. But although microbes often work incredibly well at protecting against infections or attacking tumours, we … Continue reading →

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Posted in Bacteria, Cancer Immunotherapy, Disease, Health, Immunology, Microorganisms, Oncolytic Virus, Personalised Medicine, Science, Vaccines, Virology, Viruses | Leave a comment

Leaky oncolytic viruses linked to better anti-tumour outcomes

Posted on 13 July 2020 by mmmbitesizescience

There is currently a real push in the field of oncolytic virotherapy to create tightly cancer-targeted viruses that minimise side-effects in normal healthy tissues. Yet new research from North Carolina State University suggests that using a less stringently targeted virus … Continue reading →

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Posted in Oncolytic Virus, Science, Viruses | Leave a comment

Convection currents help to deliver oncolytic virus in the brain

Posted on 13 July 2020 by mmmbitesizescience

In a Phase I clinical trial for recurrent glioma run by the University of Alabama in the USA, 15 patients have received a steady stream of oncolytic reovirus (up to 10^10 TCID50) infused directly into their brain tumour. This novel … Continue reading →

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Posted in Cancer Immunotherapy, Immunology, Oncolytic Virus, Science, Viruses | Leave a comment

Blood pressure during treatment impacts oncolytic virus therapy

Posted on 13 July 2020 by mmmbitesizescience

In an exciting new study released from the Mayo clinic, oncolytic vesicular stomatitis virus (VSV) was infused into mice with myeloma that had either just exercised (high blood pressure; ‘EX’) or were anaesthetised (low blood pressure; ‘ISO’). Mice that had … Continue reading →

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Posted in Cancer Immunotherapy, Oncolytic Virus, Science | Leave a comment