Convection currents help to deliver oncolytic virus in the brain

In a Phase I clinical trial for recurrent glioma run by the University of Alabama in the USA, 15 patients have received a steady stream of oncolytic reovirus (up to 10^10 TCID50) infused directly into their brain tumour. This novel method of infusion uses convection-enhanced delivery (continuous low-pressure catheter infusion) to deliver virus particles.

cmp3.10.3.1Lq4 0x756ffbf7

 

The best responses were: 4 patient progressed, 10 patients had stable disease and 1 had a partial response. Some adverse events were reported, but none of these were considered serious.

Overall, reovirus was safe and well tolerated in the brain, and this newly tested method of delivery looks to improve how widely reovirus gets distributed across the tumour mass.

Image credit: NIAID via flickr

Repost from the Stojdl Lab blog.

This entry was posted in Cancer Immunotherapy, Immunology, Oncolytic Virus, Science, Viruses. Bookmark the permalink.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s