That’s why I was overjoyed to hear of some new research from Australia, where a new high-strength painkiller has been isolated from the venom of the Chinese red-headed centipede, Scolopendra subspinipes mutilans.
In the insect world, centipedes are king of the hill – their venom is debilitating to their prey, helping them to capture fish, lizards, frogs and even small mammals.
Centipede venom is made up of a complex cocktail of proteins, each designed to disengage a particular biological pathway. Researchers isolated one of these proteins, µ-SLPTX-Ssm6a, and found that it blocked a specific pain receptor known as the voltage-gated sodium channel, Nav1.7.
For several types of chemical-, temperature- or acid-based pain, µ-SLPTX-Ssm6a provided better pain relief than the current gold standard, morphine. Happily, no side effects were observed.
So, µ-SLPTX-Ssm6a is a great new drug candidate for human pain relief. And since other beastie-derived venom proteins are already in clinical use – like PRIALT from the marine cone snail – µ-SLPTX-Ssm6a could make it to market before I find me a baby daddy.
Yang S, Xiao Y, Kang D, Liu J, Li Y, Undheim EA, Klint JK, Rong M, Lai R, & King GF (2013). Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models. Proceedings of the National Academy of Sciences of the United States of America, 110 (43), 17534-9 PMID: 24082113