New painkillers from black mamba venom?

After being bitten by a poisonous snake, you can probably imagine that having a good amount of venom coursing through your veins is a pretty painful process. And indeed, that is the case with many snakes, such as the Texas coral snake, whose venom contains toxins that activate pain receptors – an excellent method of warding off predators. However, the venom from the black mamba, Dendroaspis polylepis, has now been shown to contain a new class of peptides, brilliantly named, ‘mambalgins’, that actually block pain (which you may consider to be a good thing when you are being slowly consumed and digested by a black mamba). These mambalgins work by blocking both peripheral pain receptors and central neurons, and have a potent, rapid analgesic effect similar to morphine, but without the less-than-ideal side effects of being highly addictive and inducing respiratory distress. They may, therefore, have value as a novel class of naturally-occurring painkillers.

Read the original article describing this research here.

Diochot S, Baron A, Salinas M, Douguet D, Scarzello S, Dabert-Gay AS, Debayle D, Friend V, Alloui A, Lazdunski M, & Lingueglia E (2012). Black mamba venom peptides target acid-sensing ion channels to abolish pain. Nature, 490 (7421), 552-5 PMID: 23034652

Advertisements
This entry was posted in Analgesics, Science and tagged , , , , , , , . Bookmark the permalink.

One Response to New painkillers from black mamba venom?

  1. Fletcher says:

    It’s a shame you don’t have a donate button! I’d without a doubt donate to this fantastic blog! I guess for now i’ll settle for bookmarking and adding your RSS feed
    to my Google account. I look forward to new updates and will talk
    about this site with my Facebook group. Chat soon!

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s