Category Archives: Science

Vaccinia virus infections guide new vaccine designs

If we mapped out the family tree of poxviruses, then vaccinia virus (the causative agent of cowpox) and variola virus (the causative agent of smallpox) would probably be sisters. Or at the very least, cousins. This close heritage allows the … Continue reading

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Posted in Disease, Microorganisms, Science, Vaccines, Virology, Viruses | Leave a comment

Creating immune silent biotherapeutic proteins

Our beautiful immune systems have evolved to efficiently recognise foreign objects – like bacteria and viruses – that aren’t supposed to be there. This activates a huge series of biological reactions that secure the threat and restore a safe environment. … Continue reading

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Posted in Immunology, Medicine, Science | Leave a comment

Convection currents help to deliver oncolytic virus in the brain

In a Phase I clinical trial for recurrent glioma run by the University of Alabama in the USA, 15 patients have received a steady stream of oncolytic reovirus (up to 10^10 TCID50) infused directly into their brain tumour. This novel … Continue reading

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Posted in Cancer Immunotherapy, Immunology, Oncolytic Virus, Science, Viruses | Leave a comment

From tumour biopsy to personalised cancer treatment in 16 days

Every cancer patient essentially has a unique genetic disease. While certain key ‘driver’ mutations in genes such as TP53 and KRAS are almost always present, many other ‘passenger’ mutations are collected as tumours evolve that shape their genetic footprint. These … Continue reading

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Posted in Cancer Immunotherapy, Immunology, Mutations, Personalised Medicine, Science | Leave a comment

Blocking lethal viral haemorrhagic disease using interferons

Genetics can have a big impact on immune responses, making some individuals more suspectible to infections than others. In the world of small mammals, the virus LCMV-Clone 13 establishes a chronic infection in one mouse strain without too much damage. … Continue reading

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Posted in Disease, Immunology, Microorganisms, Science, Virology, Viruses | Leave a comment