Overexpressing Notch1 in regulatory T cells unlocks T cell proliferation

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Tumours typically recruit regulatory T cells (Tregs) to suppress the activity of other T cells. This effectively prevents T cells from targeting – and destroying – the tumour.

Now, a team of scientists from Harvard Medical School have shown that overexpressing a fragment of a protein called Notch 1 in Tregs reverses their activity – and helps them promote T cell function. Although this team’s research is based in a model of immune tolerance, it has key (positive) implications for cancer immunotherapy strategies.

Image credit: Scientific Illustration for the Research Scientist.

Repost from the Stojdl Lab blog.

This entry was posted in Cancer Immunotherapy, Immunology, Science. Bookmark the permalink.

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